Research on effect of ulinastatin on patients' inflammatory factors level during cardiopulmonary bypass valve replacement surgery
10.3969/J.ISSN.1672-8270.2014.12.048
- VernacularTitle:乌司他丁对体外循环瓣膜置换术患者围手术期炎性细胞因子水平的影响
- Author:
Wei HE
;
Qinghui YUAN
- Publication Type:Journal Article
- Keywords:
Valve replacement surgery;
Ulinastatin;
Cardiopulmonary bypass;
Inflammatory cytokine
- From:
China Medical Equipment
2014;(12):127-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze effect of ulinastatin on patients’ inflammatory factors level during cardiopulmonary bypass valve replacement surgery. Methods: Chosen patients accept cardiopulmonary bypass valve replacement surgery between 2011 to 2013 as research subjects, randomized to receive Ulinastatin as observation group and volume of saline as control group, testing inflammatory levels and pulmonary ventilation function difference. Results: One hour after CPB and 1h after the end of CPB, TNF-α, IL-6 level as well as A-aDO2 level of observation group were lower than control group; (2)A-aDO2 levels were positively correlated with TNF-α, IL-6 levels. Conclusion: Ulinastatin can effectively reduce cardiopulmonary bypass valve replacement surgery preoperative inflammatory cytokine levels, reducing the impact on pulmonary ventilation function, inflammatory levels and pulmonary ventilation function was negatively correlated.
