Impact of asymptomatic internal carotid artery moderate to severe stenosis and stenting on cognitive function of patients
11.3969/j.issn.1672-5921.2014.12.003
- VernacularTitle:无症状性颈内动脉中重度狭窄及支架置入对患者认知功能的影响
- Author:
Xiangqun SHI
;
Zhiqiang ZHANG
;
Liang ZHANG
;
Hongbo LUO
;
Xiaoyan ZHANG
;
Guozhen ZHANG
;
Li CAO
;
Yong WANG
- Publication Type:Journal Article
- Keywords:
Carotid stenosis;
Cognitive disorders;
Stent;
Endovascular therapy
- From:
Chinese Journal of Cerebrovascular Diseases
2014;(12):630-633
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of internal carotid artery stenosis on cognitive function of patients and the improvement of cognitive function after internal carotid artery stenting. Methods The clinical data of 92 patients with asymptomatic internal carotid artery stenosis on segment C1 segment diagnosed by cerebral angiography at the Department of Neurology,Urumqi General Hospital of Lanzhou Military Hospital from May 2007 to June 2013 were analyzed retrospectively,including 49 with moderate stenosis and 43 with severe stenosis. Thirty-one patients had stenting. The enrolled patients were evaluated with the Montreal Cognitive Scale (MoCA)score and the National Institutes of Health Stroke Scale (NIHSS) score,and the improvement of the MoCA score at 3 month after stenting was evaluated. Results (1)The MoCA score of the severe stenosis group was lower than that of the moderate stenosis group(22. 6 ± 2. 9 vs. 27. 4 ± 2. 3,P<0. 01). The patients with the MoCA score <26 was 83. 7%(36/43). It was significantly higher than 22. 4% in the moderate stenosis group (11/49). There was significant difference between the 2 groups (P<0. 01). (2)In the severe stenosis group,there was no significant difference in the preoperative MoCA score between the stenting group (22. 9 ± 3. 0)and the non-stenting group (21. 9 ± 2. 4)(P>0.05);3 months after stenting,the MoCA score (25. 4 ± 2. 7)of the stenting group was significantly better than that of the non-stenting group (22. 2 ± 2. 8). There was significant difference (P<0. 01);and after stenting,the proportion of patients with the MoCA score <26 (48. 4%,15/31)was significantly lower than those of the non-stenting (83. 3%,10/12,P=0. 037). Conclusion Severe stenosis of internal carotid artery may cause cognitive dysfunction. Carotid artery stenting is conducive to improve cognitive function in patients with severe stenosis.
