Effect Comparison of Oxycodone Hydrochloride Prolonged-release Tablets and Tramadol Hydrochloride Sustained-release Tablets in the Treatment of Cancer Pain
- VernacularTitle:盐酸羟考酮缓释片与盐酸曲马多缓释片治疗癌痛疗效比较
- Author:
Qisheng WANG
;
Yali Lü
;
Chuanjun CHEN
;
Xiaoxiao LIU
;
Bin YANG
- Publication Type:Journal Article
- Keywords:
Oxycodone hydrochloride prolonged-release tablets;
Initial treatment;
Moderate cancer pain;
De-escalation
- From:
China Pharmacist
2014;(12):2082-2084
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the efficacy and safety of oxycodone hydrochloride prolonged-release tablets and tramadol hydrochloride sustained-release tablets in the treatment of moderate cancer pain. Methods:Totally 290 cases of the patients with mod-erate pain were divided into the observation group with 148 cases and the control group with 142 cases. The observation group received oxycodone hydrochloride prolonged-release tablets, while the control group was given tramadol hydrochloride sustained-release tablets. The treatment course was 2 weeks, and the total efficiency and the incidence of adverse drug reactions( ADR) in the two groups were calculated and compared. Results:The total efficiency in the observation group and the control group was 92. 6% and 81. 7%, respec-tively, and the difference was statistically significant (P<0. 01). The incidence of ADR was 60. 1% and 57%, respectively with no significant difference (P>0.05). Conclusion: The effect of oxycodone hydrochloride prolonged-release tablets in the treatment of moderate cancer pain is better than that of tramadol hydrochloride sustained-release tablets.
