Optimization of compound lobelia gel in preparation process
- VernacularTitle:复方半边莲凝胶制备工艺优化
- Author:
Qiong CHEN
;
Haiyan WANG
;
Hongxia YU
;
Qingqing LI
;
Junjie YANG
- Publication Type:Journal Article
- Keywords:
compound lobelia;
gel;
preparation process;
orthogonal test
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(3):162-165
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the factors which affect the preparation of compound lobelia gel and establish the optimal preparation process. Methods Based on single factor test, formability, spread performance, stability were used as comprehensive evaluation indicators to select the preparation process by orthogonal design, taking the dosage of carbopol-940, drug loading, 5% hydroxy ethyl benzene ethanol solution and triethanolamine as factors.The content of scutellarin in gel was determined by HPLC.Results The best prescription of compound lobelia gel was as follows: substrat of carbopol-940 was 0.25 g, 10% Azone for promoting the permeability was 2 g, pH regulator of triethanolamine was 1.0 g, moisturizer of glycerol was 0.4 g; preservatives of 5% ethylparaben ethanol solution was 0.3 g; the drug loading was 1 g processed herbs per 1 g gel. Conclusion The preparation process of compound lobelia gel is simple, the product is texture and delicate stable.
