Role of TRPV1 in the Regulation of Gastric Motility by Electroacupuncture
10.13460/j.issn.1005-0957.2014.12.1083
- VernacularTitle:TRPV1在电针调节胃运动中的作用
- Author:
Yidan WANG
;
Xin CAO
;
Hong FENG
;
Zhi YU
;
Bin XU
- Publication Type:Journal Article
- Keywords:
Transient receptor potential vanilloid 1 (TRPV1);
Electroacupuncture;
Gastric motility;
Mouse
- From:
Shanghai Journal of Acupuncture and Moxibustion
2014;(12):1083-1085
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo discuss the role of transient receptor potential vanilloid 1 (TRPV 1) in the regulation effect of electroacupuncture on gastric motility.MethodTRPV1 gene knock-out mice (KO mice) and wild-type C57BL/6 mice (WT mice) were selected to receive acupuncture at Zusanli (ST36),Quchi (LI11), Zhongwan (CV12), and Weishu (BL21), and the intragastric pressure was observed before and after acupuncture.ResultElectroacupuncture at Zusanli caused both excitation and inhibition in WT mice, predominated by mild excitation, while electroacupuncture at Weishu, Quchi and Zhongwan all caused inhibition effect; in the KO mice, electroacupuncture at Zusanli, Quchi, Zhongwan, and Weishu all inhibited gastric motility.Conclusion TRPV1 bears certain regulating effect on gastric motility, andacupuncture can inhibit the gastric motility in TRPV gene KO mice.
