Design, synthesis and anti-platelet aggregation activities of ligustrazine-tetrahydroisoquinoline derivatives.
- Author:
Di XIE
;
Enli ZHANG
;
Jiaming LI
;
Jie WANG
;
Guangwei HE
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2015;50(3):326-31
- CountryChina
- Language:Chinese
-
Abstract:
Abstract: Fifteen novel ligustrazine-tetrahydroisoquinoline derivatives were designed and synthesized according to the association principle of pharmaceutical chemistry. The structures were identified by IR, NMR and ESI-MS. The inhibitory activities of platelet aggregation induced by ADP and AA have been measured by Bron method. Preliminary pharmacological results showed that compounds 7g, 7h and 7n had potent inhibitory activity against platelet aggregation induced by AA, and the compound 7o showed significant inhibitory activity against platelet aggregation induced by ADP.
