Thought and method of reproductive toxicity research in traditional Chinese medicine.
- Author:
Jiayin HAN
;
Yi YAN
;
Aihua LIANG
;
Yushi ZHANG
;
Chunying LI
;
Yong ZHAO
;
Yuting LU
;
Hongyu CUI
;
Guiqin LI
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2014;49(11):1498-503
- CountryChina
- Language:Chinese
-
Abstract:
Reproductive toxicity research takes an important place in traditional Chinese medicine pre-clinical safety evaluation. Modern reproductive toxicity experiment includes drug-related miscarriage, fetal death, teratism, and adverse effects on fertility, genital system, embryonic development and fetus, which is different from contraindicated in pregnancy in traditional Chinese medicine theory. Now the three-phases reproductive toxicity study is the method mainly applied in traditional Chinese medicine reproductive toxicity evaluation. Besides that, alternative methods of whole embryos culture and embryonic stem cell test are also used in traditional Chinese medicine embryo toxicity evaluation. This article reviews research progress and pre-clinical evaluation on reproductive toxicity of traditional Chinese medicine.
