Study on the relationship between neutrophil-lymphocyte ratio and microangiopathy in type 2 diabeted mellitus

VernacularTitle:中性粒细胞与淋巴细胞比值与2型糖尿病微血管病变的相关性研究
Author: Xiaohui ZHANG ; Wei ZHAO ; Xiao ZHENG ; Ling FENG ; Shengqian ZHU ; Hong ZHANG
Publication Type:Journal Article
Keywords: Neutrophil-lymphocyte ratio; Diabetes mellitus,type 2; Microangiopathy; Diabetic nephropathy
From: Chinese Journal of Endocrinology and Metabolism 2014;30(9):752-754
CountryChina
Language:Chinese
Abstract: To explore the relationship between neutrophil-lymphocyte ratio (NLR) and microangiopathy in type 2 diabetes mellitus,303 type 2 diabetic patients were divided into non-microangiopathy (N),diabetic nephropathy (DN),diabetic retinopathy (DR),and DN combined with DR (DNR) groups.The clinical and biochemical data were collected for comparing the differences in NLR among four groups.The results showed that NLR,white blood cell count,neutrophil count in DN,DR,and DNR groups were significantly higher than that in N group,and NLR in DNR group was higher than those in DN and DR groups (3.35 ± 1.35 vs 2.05 ± 0.68 and 1.89 ±0.60,both P＜ 0.05).However,the lymphocyte count in DNR was lower than that in other three groups.The multifactor logistic regression analysis showed that NLR was a risk factor for predicting microangiopathy in type 2 diabetic patients(OR=6.643,95％ CI3.502-12.601,P＜0.01).