Relationship between osteocalcin and metabolism of glucose and lipid in type 2 diabetes

VernacularTitle:2型糖尿病患者中骨钙素与糖脂代谢之间的关系
Author: Xiaoyu MA ; Hong HONG ; Xiujuan LYU ; Fenqin CHEN ; Qiuyue WANG
Publication Type:Journal Article
Keywords: Osteocalcin; Glucose and lipid metabolism; Diabetes mellitus,type 2
From: Chinese Journal of Endocrinology and Metabolism 2014;30(9):749-751
CountryChina
Language:Chinese
Abstract: A total of 185 patients with type 2 diabetes mellitus (T2DM) were consisted of male group (n =95) and postmenopausal female group (n =90).The parameters of fasting plasma glucose,HbA1c,fasting insulin,fasting C peptide,homeostasis model assessment insulin resistant index (HOMA-IR) and β-cell function (HOMA-β),blood lipid,body mass index,and waist to hip ratio were collected and analyzed by Pearson correlation analysis and stepwise multiple regression analysis.The relationships between osteocalcin and these parameters were investigated.The results revealed that osteocalcin was negatively correlated with HbA1C (P＜0.05),and osteocalcin was an independent relevant factor affecting HbA1Clevels.Osteocalcin may be involved in the regulation of glucose metabolism in T2DM.