Effect of metformin on SFRP5 release and insulin resistance in diabetic rat

VernacularTitle:二甲双胍对糖尿病大鼠SFRP5分泌及胰岛素抵抗的影响
Author: Jiafeng WANG ; Jianjun JIANG ; Yuan SHAO ; Gennian WANG ; Mo CHEN ; Youcheng ZHANG
Publication Type:Journal Article
Keywords: Secreted frizzled-related protein 5; Metformin; Diabetes; Liver; p-JNK
From: Chinese Journal of Endocrinology and Metabolism 2014;30(7):614-616
CountryChina
Language:Chinese
Abstract: Diabetic rat model accompanied by insulin resistance was established by intraperitoneal injection of streptozocin.Following metformin treatment for 5 weeks,ELISA was used to detect the level of plasma secreted frizzled-related protein (SFRP) 5,and immunohistochemistry was used to detect the expression of p-JNK in the liver.insulin resistance(IR) and p-JNK were significantly increased in diabetic group compared with the control group (P＜0.05),while plasma SFRP5 level was reduced (P＜0.01).After metformin treatment,the plasma SFRP5 levels were significantly increased (P＜0.05),while IR and p-JNK was decreased (P＜O.05).Metformin may ameliorate insulin resistance via upregulating the SFRP5 expression of diabetic rats.