Association between serum fetuin A and diabetic nephropathy in patients with type 2 diabetes
10.3760/cma.j.issn.1000-6699.2014.07.012
- VernacularTitle:2型糖尿病患者血清胎球蛋白A水平与糖尿病肾病的相关性
- Author:
Huixiang JU
;
Zhongwei ZHOU
;
Mingzhong SUN
;
Yuqiao JI
;
Jie ZHANG
;
Sicong CHEN
;
Jianwei JI
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Fetuin-A;
Diabetes mellitus,type 2
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(7):592-594
- CountryChina
- Language:Chinese
-
Abstract:
The association between serum fetuin A and diabetic nephropathy (DN) in patients with type 2 diabetes mellitus(T2DM) was investigated.Serum levels of fetuin-A and adiponectin were measured by ELISA and the clinical data were collected in 101 T2DM patients with normal albuminuria (NA group),87 patients with microalbuminuria (MA group),44 patients with overt albuminuria (OA group),and 130 normal control subjects (NC group).Fetuin-A levels increased progressively from NC,NA,MA,to OA groups,and there were significant differences among groups(P＜0.05 or P＜0.01).Fetuin-A level in patients was positively associated with duration of illness,urinary albumin to creatinine ratio (ACR),fasting blood glucose,2-hour postprandial blood glucose,and C-reactive protein(CRP,P＜0.05 or P＜0.01),but was negatively associated with age and adiponectin (all P＜ 0.01).Multiple stepwise regression analysis indicated that duration of diabetes,fetuin-A,CRP,and adiponectin were independent determinants for ACR (all P ＜ 0.01).Fetuin-A may be involved in the development and pathogenesis of DN by proinflammatory effects and repressing adiponectin production.
