Experimental study of the appropriate time to block adrenal androgens in endocrine therapy of prostate cancer
10.3760/cma.j.issn.1000-6702.2014.08.017
- VernacularTitle:前列腺癌内分泌治疗中阻断肾上腺源性雄激素时机的实验研究
- Author:
Shuai MENG
;
Yanqun NA
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Adrenal glands;
Androgens;
Endocrine therapy;
Mice,SCID
- From:
Chinese Journal of Urology
2014;35(8):625-628
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the appropriate time to block adrenal androgens in endocrine therapy of prostate cancer.Methods An human androgen-dependent prostate carcinoma xenograft model in SCID mice was established with LNCaP cells.Firstly,the serum PSA and tumor volume of 2 groups (castrated and not castrated) were measured on the 1,4,7,10,14,17,21,28,35,42,49 and 56 day to determine the recurrent time of prostate cancer after castration.Secondly,3 different groups of castration and adrenalectomy at the same time,adrenalectomy in recurrence after castration and sham adrenalectomy in recurrent after castration,were set to measure the serum PSA and tumor volume on the 1,4,7,10,14,17,21,28,35,42,49 and 56 day.The tumor tissues of 5 groups were harvested to measure testosterone concentration,and tumor progress in these groups was compared.Results The recurrence time was 14 days in castrated group,21 days in group with castration and adrenalectomy at the same time and 35 days in group with adrenalectomy in recurrence after castration.The testosterone concentration in tumor tissues was (2.69± 0.21) pmol/g in the group with castration and adrenalectomy at the same time,and (2.16±0.13) pmol/g in the group with adrenalectomy in recurrence after castration,and the difference was significant (P＜0.05).Conclusion Compared with the therapy of castration and adrenalectomy at the same time,the therapy of adrenalectomy in recurrence after castration may have slower progress course in prostate cancer.
