Comparison of sertraline plus doxazosin and tadalafil in the treatment of premature ejaculation
10.3760/cma.j.issn.1000-6702.2014.09.020
- VernacularTitle:舍曲林联合多沙唑嗪或他达拉非治疗早泄的疗效比较
- Author:
Jiangang PAN
;
Jiajun YAN
;
Zhengang LUO
;
Yi ZHOU
- Publication Type:Journal Article
- Keywords:
Tadalafil;
Sertraline;
Doxazosin;
Premature ejaculation
- From:
Chinese Journal of Urology
2014;35(9):708-711
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and safety of sertraline plus doxazosin and tadalafil in the treatment of premature ejaculation (PE).Methods From Feb.to Aug.2011,One hundred and five patients from 19 to 52 years old with PE but without any obvious organic cause were enrolled in this study.They were randomly divided into Groups A,B and C in equal number.All the three Groups received 50 mg sertraline daily 4 to 6 hours before planned sexual activity for 12 weeks,Group B were added with 4 mg Doxazosin every day 8 to 9 hour before planned sexual activity,and Group C were given 20 mg Tadalafil as needed one hour before planned sexual activity.The mean intravaginal ejaculatory latency time,the mean intercourse satisfaction domain values and the sexual activity satisfaction domain values of the patient couples of group A before treatment were 0.6±±0.1 min,8.3±1.3,5.3±1.4; Group B were 0.6±0.1 min,7.6± 1.5,5.6± 1.5 ; Group C were 0.6±0.1 min,8.1 ± 1.1,5.0± 1.2,respectively.We observed before and after the treatment for 12 weeks and the effects were evaluated.Results The mean intravaginal ejaculatory latency time,the mean intercourse satisfaction domain values and the sexual activity satisfaction domain values of the patient couples of group A were 3.9±0.l min,10.6±0.1,9.7±0.1,respectively; Group B were 4.5 ± 0.1 min,12.8±1.3,11.9±1.6; Group C were 5.6±0.3 min,14.6±1.4,13.1±1.5,respectively.The mean intravaginal ejaculatory latency time improved in all of the 3 groups,but more significantly in Group B and C (P<0.05).The mean intercourse satisfaction domain values of the IIEF were significantly greater in Group B and C than in Group A (P<0.05) after the treatment; and the sexual activity satisfaction domain values of the patient couples were greater in Group C than in Group B after the treatment,but it is not significant.As for the side effects,5 cases in group A felt headaches and dizzy (14.3%),8 cases in group B felt headaches and dizzy (22.9%),and in group C,9 cases felt headaches and dizzy (25.7%),6 cases experienced flushing episodes on the body (17.1%).there was a higher rate of headaches (P<0.05) and flushing episodes (P<0.05) in Group B and C than in Group A.Conelusions Sertraline combined with Tadalafil or Doxazosin can achieve significantly better results than sertraline alone in patients with premature ejaculation.However,the combined treatment is associated with a slightly increased in the drug related side effects,and there is no significant difference in the efficacy of Sertraline Plus Tadalafil or Doxazosin in the treatment of premature ejaculation.