Mechanism of dedifferentiation in differentiated thyroid cancer
10.3760/cma.j.issn.2095-2848.2014.04.016
- VernacularTitle:甲状腺癌失分化机制的研究进展
- Author:
Yingjie ZHANG
;
Yansong LIN
;
Jun LIANG
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Radiotherapy;
Iodine radioisotopes;
Genes;
Mutation;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2014;34(4):327-330
- CountryChina
- Language:Chinese
-
Abstract:
131 I-metabolizing genes are markers for differentiation of thyroid carcinoma.The loss or down-regulation of these genes represents progression of dedifferentiation,which results in low 131 I uptake and suggests a poor prognosis.The mechanism of dedifferentiation of DTC is important for treatment.This article reviews the mechanism of dedifferentiation from 131I radiation damage,gene mutation,tumor markers and protein.
