Molecular imaging of tumor by target microRNAs
10.3760/cma.j.issn.2095-2848.2014.04.018
- VernacularTitle:MicroRNAs靶向肿瘤分子显像
- Author:
Weidong YANG
;
Jie TIAN
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
Fluorescence imaging;
Bioluminescent imaging;
Radionuclide imaging;
MiRNAs;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2014;34(4):335-338
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are a novel class of small noncoding RNAs that regulate gene expression by targeting mRNAs for either cleavage or translational repression.Accumulated studies show that miRNAs aberrantly expressed in tumors are closely related with tumorogenesis and could be potential tumor biomarkers.It will be helpful in the diagnosis,prognosis and(or) predicting treatment response of tumor by imaging miRNAs expression.Several molecular imaging methods,including the optical imaging,radionuclide imaging and multimodality imaging,have been successfully used to visualize miRNAs,miRNAs,a new molecular imaging target,may explore a new field for tumor diagnosis and therapy.
