Research advances on pathogenic mechanisms of HBV-related intrahepatic cholangiocarcinoma
10.3760/cma.j.issn.1007-8118.2014.08.018
- VernacularTitle:HBV相关肝内胆管细胞癌致病机制的研究进展
- Author:
Peiyi LIN
;
Xueping ZHOU
;
Zhisheng CHEN
;
Lisheng LYU
;
Zhaohui TANG
- Publication Type:Journal Article
- Keywords:
Cholangiocarcinoma,intrahepatic;
Hepatilic B virus;
Liver neoplasms
- From:
Chinese Journal of Hepatobiliary Surgery
2014;20(8):617-620
- CountryChina
- Language:Chinese
-
Abstract:
Intrahepatic cholangiocarcinoma is the second most common intrahepatic primary liver tumor after hepatocellular carcinoma (HCC).Epidemiological study suggests a strong correlation between HBV infection and ICC development.This review focused on the potential mechanisms of HBV-induced ICC and gives a primary summary of suggested hypothesis,which included:(1) HBV infection of liver stem/progenitor cells will indirectly lead to HBV infection of intrahepatic biliary epithelial cells and lead to the development of ICC; (2) the changed microenvironment of intrahepatic biliary epithelial cells by HBV infection eventually results in carcinogenesis ; (3) the HBV infection of hepatic sten/progenitor cell can transform into tumor-like stem cells and ultimately differentiate into ICC-like tumor cells.
