Research advances on the pathogenesis of congenital biliary atresia
10.3760/cma.j.issn.1007-8118.2014.08.017
- VernacularTitle:先天性胆道闭锁发病机制的研究进展
- Author:
Yanbin FANG
;
Suolin LI
;
Weili XU
- Publication Type:Journal Article
- Keywords:
Biliary atresia,congenital;
Hereditary inclination;
Virus infection;
Immune reaction;
Epithelial-mesenchymal transition
- From:
Chinese Journal of Hepatobiliary Surgery
2014;20(8):612-616
- CountryChina
- Language:Chinese
-
Abstract:
Biliary atresia is the most common obstructive cholangiopathy in infants.Its etiology and pathogenesis still remains unclear.Hypothetical mechanisms include genetic predisposition,viral infection,chronic inflammation or autoimmune-mediated bile duct injury,and congenital malformations of vessels or biliary tracts.The key pathogenesis is related to viral infection and immunoreaction.This review overviewed the research progress in the pathogenesis of biliary atresia in the past few years.
