Preliminary study on relationship between DVH parameters and late side effects of rectum in external-beam radiotherapy combined with CT-based brachytherapy for locally advanced cervical cancer
10.3760/cma.j.issn.1004-4221.2014.05.001
- VernacularTitle:宫颈癌常规放疗联合腔内三维放疗的初步研究
- Author:
Jusheng AN
;
Manni HUANG
;
Yingjie XU
;
Suiyang XIONG
;
Xiaomeng DU
;
Lingying WU
;
Jianrong DAI
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms/radiotherapy;
Uterine cervical neoplasms/brachytherapy;
Dosimetry;
Side effect
- From:
Chinese Journal of Radiation Oncology
2014;23(5):373-376
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between dose-volume histogram (DVH) parameters and the late side effects (LSE) of the rectum in external-beam radiotherapy combined with computed tomography (CT)-based brachytherapy for locally advanced cervical cancer.Methods From 2008 to 2011,18 patients with stage ⅡB-ⅢB cervical cancer received external-beam radiotherapy and CTbased brachytherapy.The DVH parameters of high-risk clinical target volume (HR CTV) D90,point A dose,and D1 cm3 and D2 cm3 of the rectum and bladder were calculated by Oncentra HDR treatment planning system.Survival outcomes were followed up and rectal LSE were evaluated by RTOG/EORTC grades.Results The point A dose and HR CTV D90 were (93.0 ± 5.5) Gy and (73.6 ± 11.9) Gy,respectively.The median follow-up was 26 months.No recurrence was found during follow-up.Eight patients had mild and moderate rectal LSE,and their rectum D2 cm3 and D1 cm3 were significantly higher than those of patients without mild and moderate rectal LSE (D2 cm3:(87.4 ± 3.8) Gy vs.(75.8 ± 7.4) Gy,P =0.004 ; D1 cm3:(96.4±6.6) Gy vs.(80.5± 7.1) Gy,P=0.001).Conclusions HR CTV D90 in CT-based brachytherapy for locally advanced cervical cancer might be lower than that in the MRI-based plan.Rectum D2 cm3 is recommended to be less than 75 Gy.
