Central nervous system involvement in relapsing polychondritis: 5 case reports and review of literatures
10.3760/cma.j.issn.1007-7480.2014.08.002
- VernacularTitle:复发性多软骨炎合并中枢神经系统损害五例并文献复习
- Author:
Ya LI
;
Li WANG
;
Qingjun WU
;
Min QIAN
;
Di WU
;
Guiren RUAN
;
Fengchun ZHANG
- Publication Type:Journal Article
- Keywords:
Polychondritis,relapsing;
Central nervous system
- From:
Chinese Journal of Rheumatology
2014;18(8):511-514
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical profile of patients with central nervous system (CNS) involvement in relapsing polychondritis (RP).Methods Clinical data of five patients of RP with CNS lesions were collected,and compared with those from the literatures.T test and Fisher exact test were used for statistical analysis.Results Among 205 patients with RP in Peking Union Medical College Hospital,five cases (2.4％) had CNS damage.All 5 cases presented an active onset and occurred in the active phase of RP.All of them manifested as meningoencephalitis,complicating cranial neuropathies in 2 cases (2/5).Cerebrospinalfluid examination revealed non-specific meningeal inflammation,and magnetic resonance image (MRI) showed long T2 signals in brain lesions.Four patients (4/5) showed good response to high-dose glucocorticosteroid plus immunosuppressive agent combined therapy.The average age of our patients was younger than those in the literatures [(44± 14),(58± 11) years,respectively; t=2.547,P＜0.05],while other clinical features was not significantly different between the two groups.Conclusion CNS involvement is a rare condition in RP patients,and usually occurrs in the early course of active RP.Meningoencephalitis/ meningitis is the major clinical manifestations.MRI and cerebrospinal fluid examination may help to confirm the diagnosis.Treatment with corticosteroid and immunosuppressant can result in favorable response.
