Photodynamic therapy of basal cell carcinoma and factors affecting the response to treatment
10.3760/cma.j.issn.1008-1372.2014.08.011
- VernacularTitle:光动力治疗基底细胞癌的疗效和影响因素
- Author:
Wei LI
;
Ling LIN
;
Yumei LIU
;
Ji LI
;
Hongfu XIE
;
Xibao ZHANG
- Publication Type:Journal Article
- Keywords:
Photochemotherapy;
Carcinoma,basal cell/therapy;
Aminolevulinic acid/therapeutic use;
Photosensitizing agents/therapeutic use;
Treatment outcome
- From:
Journal of Chinese Physician
2014;16(8):1044-1046
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate efficacy and safety of photodynamic therapy on basal cell carcinomas.Methods Twenty three cases of basal cell carcinomas were given with photosensitizer 5-amino acid (ALA) ketone spreading on skin lesions.Reddish illumination was taken at 4h later with energy density at 100 J/cm2,40 min/time,and weekly for a total of 4 weeks; and 2 year followup in the study was evaluated recurrence retrospectively.Results Among twenty three patients with basal cell carcinomas,15 were cured(65.22％),5 partially (21.74％) remitted,and 3 ineffective (13.04％),with the efficiency 86.96％.None of the resolved lesions recurred during the 6-month follow-up period,and 3 cases were recurred within 1 year (20％).Repeated ALA-photodynamic therapy (PDT) treatment,recurred lesions were completely resolved.There were no additional recurrences after 2 year.ALA-PDT was well tolerated,and adverse effects were limited to mild local pain and erythema.Only three patients were complained of erythema and edema.Complete response rate was higher in younger patients (t =-2.94,P ＜0.01) and those with smaller lesions (t =-5.92,P ＜ 0.01).Superficial type had also significant higher response rate (x2 =27.17,P ＜ 0.01).Conclusions The application of photodynamic therapy in treatment of basal cell carcinoma is effective with less painfulness,non-invasiveness,and without side effect.It demonstrated a good efficacy and satisfactory cosmetic outcomes.
