Effects of cellular microenvironment on the efficacy of biomacromolecular therapies
10.3760/cma.j.issn.1673-4181.2014.04.014
- VernacularTitle:细胞微环境对生物活性大分子疗效的影响
- Author:
Mohan WANG
;
Duohong ZOU
;
Jiacai HE
- Publication Type:Journal Article
- Keywords:
Biomacromolecule;
Therapy;
Cellular microenvironment
- From:
International Journal of Biomedical Engineering
2014;37(4):247-250
- CountryChina
- Language:Chinese
-
Abstract:
Currently,with the rapid development of drug delivery technologies,more and more efforts are taken into the efficient therapies for various diseases by delivering biologically-active macromolecules into the target cells directly.Although a certain number of positive treatment results were obtained from the therapies by using the biomacromolecules to cure some diseases,the microenvironment around the target cell still has a great influence on the final treatment effect.Since many diseases and injuries interfere the normal architecture of the extracellular matrix (ECM),the cell adhesion to ECM and the subsequent cellular activities,the normal microenvironment of the cell plays a critical role in maintaining body balance,tissue regeneration and repair.Given these points,this paper reviews the effects of the cellular microenvironment constructed by ECM on the efficacy of bioactive macromolecules,and provides a theoretical basis for future drug design and synthesis of pharmaceuticals.
