Clinicopathological and prognostic significance of PRKACB expression in non-small cell lung carcinoma

VernacularTitle:PRKACB 表达在非小细胞肺癌的临床病理意义及预后分析
Author: Wenjun JIANG ; Ye TIAN ; Chengyang SONG ; Dali TIAN
Publication Type:Journal Article
Keywords: Carcinoma; non-small-cell lung; Protein kinase cAMP-dependent catalytic beta ( PRKACB ); Expression
From: Chinese Journal of Primary Medicine and Pharmacy 2014;(20):3048-3050
CountryChina
Language:Chinese
Abstract: Objective To detect expression of PRKACB protein in non-small cell lung cancer ,thus to study its clinical significance and to analyze the relationship between PRKACB expression and prognosis .Methods We detected the PRKACB protein using immunohistochemistry in 109 lung cancer tissues and corresponding adjacent 20 normal tissues of non-small cell lung cancer patients .Results Compared with normal tissues , the level of PRKACB significantly decreased in lung cancers (χ2 =25.217,P<0.05),and was associated with differentiation (χ2 =9.664,P<0.05),lymph node metastasis(χ2 =4.430,P<0.05),and TNM staging(χ2 =4.430,P<0.05). Furthermore,the low expression of PRKACB protein was correlated with poor prognosis ( overall survival and disease-free survival ) of the patients .Conclusion PRKACB was lowly expressed in non-small cell lung cancer ,and associat-ed with clinical features ,which indicated its important role in clinical diagnosis of non-small cell lung cancer .