Effect of carvedilol on heart rate variability and plasma NT-proBNP in patients with chronic heart failure
10.3760/cma.j.issn.1008-6706.2014.20.030
- VernacularTitle:卡维地洛对慢性心力衰竭患者血浆N末端脑利钠肽原和心率变异性的影响
- Author:
Ping SHI
;
Tao XU
;
Shufen SONG
- Publication Type:Journal Article
- Keywords:
Heart failure;
Carvedilol;
Heart rate variability;
N-terminal brain natriuretic peptide
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(20):3120-3122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of carvedilol on heart rate variability and plasma N-terminal brain natriuretic peptide(NT-proBNP) in patients with chronic heart failure.Methods 106 patients with chronic heart fail-ure were randomly divided into the two groups ..53 patients in the control group were treated by the conventional ther-apy plus metoprolol ,while 53 patients in the observation group were treated by the conventional therapy plus carve -dilol.They were treated for six months .Heart rate variability and plasma NT-proBNP were measured before and after treatment in the two groups .Results The total effective rate of the control group was 83.0%,which was significantly lower than 94.3% of the observation group (χ2 =6.26,P<0.05).Before treatment,SDNN,SDANN,RMSSD and PNN50 between the two groups had no significant differences (t=0.284,0.360,0.410,0.302,all P>0.05).After treatment,SDNN,SDANN,RMSSD and PNN50 were significantly increased (t=3.095,9.184,3.622,4.302,2.261, 4.522,2.921,2.992,P <0.05 or P <0.01).Compared with the control group,those in the observation group increased more significantly (t=8.065,3.116,3.209,2.171,P<0.05 or P<0.01).After treatment,plasma NT-proBNP were significantly decreased in the two groups (t=7.093,9.773,all P<0.01).Compared with the control group,plasma NT-proBNP of the observation group decreased more significantly (t=4.773,P<0.01).Conclusion Carvedilol can more significantly improve heart rate variability and plasma NT-proBNP in patients with chronic heart failure.
