Effects of calcium dobesilate plus laser on serum VEGF and IGF-1 in patients with diabetic retinopathy
10.3760/cma.j.issn.1008-6706.2014.20.035
- VernacularTitle:羟苯磺酸钙联合激光治疗对糖尿病视网膜病变患者血管内皮生长因子和胰岛素样生长因子-1的影响
- Author:
Ying ZHAO
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy;
Calcium dobesilate;
Vascular endothelial growth factor;
Insulin-like growth factor-1
- From:Chinese Journal of Primary Medicine and Pharmacy
2014;(20):3131-3133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of calcium dobesilate plus laser on serum vascular endothelial growth factor ( VEGF ) and insulin-like growth factor-1 ( IGF-1 ) in patients with diabetic retinopathy .Methods 82 patients(93 eyes) were randomly divided into two groups ,the control group(n=41 cases,46 eyes) and the obser-vation group(n=41 cases,47 eyes).The control group was treated through laser ,while the observation group was treated through laser plus calcium dobesilate .Serum VEGF and IGF-1 were measured before and after treatment . Results Before treatment,visual acuity had no significant difference between the two groups (t=0.601,P>0.05). After treatment,visual acuity was improved in 30 eyes in the control group with improving rate of 65.2%,visual acuity improved in 38 eyes in the observation group with improving rate of 80.9%.The improving rate of visual acuity in the observation group was significantly higher than that of the control group (χ2 =6.92,P<0.05).The total effective rate of the control group was 73.9%,which was significantly lower than 87.2%in the observation group (χ2 =9.28,P<0.05). Serum VEGF and IGF-1 had no significant differences before and after treatment in the control group ( t=0.613, 0.496,all P>0.05).After treatment,serum VEGF and IGF-1 in the observation group were (91.4 ±25.1)ng/L and (121.6 ±21.7)mg/L,which were significantly lower than those before treatment (t=3.721,5.992,all P<0.05). Conclusion Calcium dobesilate plus laser can significantly decrease serum VEGF and IGF-1 in patients with diabet-ic retinopathy .
