Eradication Rate of Bismuth-containing Quadruple Regimens Recommended by the Chinese Consensus Report on Management of Helicobacter pylori Infection
10.3969/j.issn.1008-7125.2014.09.005
- VernacularTitle:我国幽门螺杆菌感染处理共识推荐的铋剂四联方案根除率分析
- Author:
Xiaoling JIANG
;
Huiyun YUAN
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Eradication Therapy;
Consensus;
Literature Retrieval;
Bismuth;
Furazolidone
- From:
Chinese Journal of Gastroenterology
2014;(9):531-536
- CountryChina
- Language:Chinese
-
Abstract:
Background:With the increasing of antibiotic resistance and decreasing of eradication rate of standard triple therapy, bismuth-containing quadruple regimens were recommended by the update Chinese consensus report for eradication of Helicobacter pylori( Hp ) infection. Aims:To evaluate the eradication rate of the recommended bismuth-containing quadruple regimens for guiding the choice of low cost and high efficiency eradication regimens. Methods:A search of online database( CNKI,Wanfang and VIP)was carried out. Clinical trials published in Chinese from 2011 to 2013 that evaluated the eradication rate of the recommended bismuth-containing quadruple regimens were retrieved. Data were extracted by standardized data forms. According to the categories raised by Dr. Graham,the eradication rates were graded and analyzed. Results:A total of 166 eligible articles including 192 clinical trials for eradication of Hp infection were obtained. Nationwidely,the eradication rates of amoxicillin-containing regimens were acceptable,among which PAFB( PPI+amoxicillin+furazolidone+bismuth)regimen was more prone to achieve excellent eradication rate(≥95%). PACB ( PPI+amoxicillin+clarithromycin+bismuth)regimen was optimal for Hp eradication in East China,and PAFB regimen was optimal in Central South China. A 14-day treatment course was appropriate. Conclusions:In the recommended bismuth-containing quadruple regimens,PAFB regimen might be the first choice nationwidely for eradication of Hp infection in individuals without amoxicillin-hypersensitivity because of its low cost and high efficiency. The recommended treatment course is 14-day.
