A Case-control Study on Relationship between Helicobacter pylori Infection and Duodenal Brunner ’s Gland Hyperplasia
10.3969/j.issn.1008-7125.2014.09.010
- VernacularTitle:幽门螺杆菌感染与十二指肠Brunner腺增生关系的病例对照研究
- Author:
Wenxiao LI
;
Feng GAO
;
Yan FENG
;
Jun ZHANG
- Publication Type:Journal Article
- Keywords:
Brunner Glands;
Hyperplasia;
Helicobacter pylori;
Case-Control Studies
- From:
Chinese Journal of Gastroenterology
2014;(9):554-556
- CountryChina
- Language:Chinese
-
Abstract:
Background:The incidence of duodenal Brunner’s gland hyperplasia is low and the etiology and pathogenesis has not yet been clarified. Aims:To investigate the relationship between duodenal Brunner’s gland hyperplasia and Helicobacter pylori( Hp ) infection. Methods:A total of 96 patients with duodenal Brunner ’s gland hyperplasia diagnosed by pathological examination from October 2005 to December 2013 at People’s Hospital of Xinjiang Uygur Autonomous Region were enrolled in this study,and 270 cases without duodenal Brunner’s gland hyperplasia were served as controls. Hp infection was detected by 14 C-urea breath test( 14 C-UBT). The relationship between duodenal Brunner’s gland hyperplasia and Hp infection was analyzed. Results:In the duodenal Brunner ’s gland hyperplasia group,75 patients were Hp positive,the proportion of Hp infection was 3. 57( 75/21 ). In the control group,110 cases were Hp positive,the proportion of Hp infection was 1. 45(160/110). The difference between the two groups was statistically significant(χ2 =10. 97,P=0. 001). Hp infection was a risk factor of the genesis of duodenal Brunner’s gland hyperplasia( OR=2. 46, 95% CI:1. 44-4. 19). Conclusions:Hp infection may be related with the genesis of duodenal Brunner’s gland hyperplasia.
