Progress in Research on HER2 and Gastric Cancer
10.3969/j.issn.1008-7125.2014.09.016
- VernacularTitle:HER2与胃癌的研究进展
- Author:
Zhaochun CHI
;
Aiping CHEN
- Publication Type:Journal Article
- Keywords:
HER2;
Stomach Neoplasms;
Trastuzumab;
Immunohistochemistry;
In Situ Hybridization;
Prognosis
- From:
Chinese Journal of Gastroenterology
2014;(9):573-576
- CountryChina
- Language:Chinese
-
Abstract:
This paper reviewed the progress in research on HER2 and gastric cancer,introducing the structure, signaling pathways,detection method and detection rate of HER2,the therapeutic effect of trastuzumab,a humanized anti-HER2 monoclonal antibody on gastric cancer,and the correlation between HER2 and prognosis of gastric cancer. Studies showed that HER2-positive was a factor with poor prognosis,and trastuzumab combined with chemotherapy was a new treatment option for patients with HER2-positive advanced gastric and gastroesophageal junction cancer or with liver metastases,which could significantly improve the prognosis.
