Effect of Addition of Flupentixol and Melitracen Tablets on Irritable Bowel Syndrome with Depression and Anxiety
10.3969/j.issn.1008-7125.2014.08.010
- VernacularTitle:加用氟哌噻吨美利曲辛片治疗肠易激综合征伴抑郁焦虑的疗效
- Author:
Haihui HUANG
;
Jianguo WU
- Publication Type:Journal Article
- Keywords:
Irritable Bowel Syndrome;
Depression;
Anxiety;
Flupentixol And Melitracen;
Therapy
- From:
Chinese Journal of Gastroenterology
2014;(8):489-491
- CountryChina
- Language:Chinese
-
Abstract:
Background:Psychological factor plays an important role in the pathogenesis of functional gastrointestinal disorders. Depression,anxiety may share the pathogenesis with irritable bowel syndrome( IBS),therefore,more and more attention has been paid to anti-depression and anti-anxiety in the treatment of IBS. Aims:To evaluate the effect of addition of flupentixol and melitracen tablets on IBS with depression and anxiety. Methods:Sixty IBS patients with depression and anxiety were randomly divided into control group and treatment group. Patients in control group were given live combined Bacillus subtilis and Enterococcus faecium enteric-coated capsules and trimebutine maleate,while paitents in treatment group were received flupentixol and melitracen tablets in addition to the above-mentioned medicine. Treatment course was 8 weeks. Hamilton depression scale,Hamilton anxiety scale and symptom score were evaluated before and after treatment. Results:Compared with control group,depression and anxiety in treatment group were obviously improved(P<0. 05);the relief rates of abdominal pain and diarrhea were significantly increased( P <0. 05 );and the total symptom score were significantly decreased(P<0. 05);the total effective rate was significantly increased(93. 3% vs. 76. 7%,P<0. 05). However,no significant difference in incidence of adverse reaction was found between the two groups. Conclusions:Additon of flupentixol and melitracen tablets can significantly improve the curative effect on IBS with depression and anxiety.
