Regulatory Mechanism of Integrins on Pancreatic Cancer Cells and Progress in their Application
10.3969/j.issn.1008-7125.2014.07.009
- VernacularTitle:整合素对胰腺癌细胞的调节机制及其应用研究进展
- Author:
Sijia HE
;
Leiming XU
- Publication Type:Journal Article
- Keywords:
Integrins;
PancreaticNeoplasms;
SignalTransduction
- From:
Chinese Journal of Gastroenterology
2014;(7):436-438
- CountryChina
- Language:Chinese
-
Abstract:
Integrins are a family of cell adhesion receptors that mediate cell-cell and cell-extracellular matrix adhesion, and interact with cytokines through a bidirectional signal transduction,thus regulating the biological behavior of pancreatic cancer cells,such as proliferation,apoptosis,invasion,and migration etc. Molecular and animal studies indicated that integrins targeted methods might benefit the early diagnosis and drug therapy of pancreatic cancer,which offered a new approach for the study of diagnosis and treatment of pancreatic cancer.
