CHINET 2013 surveillance of bacterial resistance in China
- VernacularTitle:2013年中国CHINET细菌耐药性监测
- Author:
Fupin HU
;
Demei ZHU
;
Fu WANG
;
Xiaofei JIANG
;
Ziyong SUN
;
Zhongju CHEN
;
Zhidong HU
;
Jin LI
;
Yi XIE
;
Mei KANG
;
Yingchun XU
;
Xiaojiang ZHANG
;
Zhaoxia ZHANG
;
Ping JI
;
Chuanqing WANG
;
Aimin WANG
;
Yuxing NI
;
Jingyong SUN
;
Yunsong YU
;
Jie LIN
;
Yunzhuo CHU
;
Sufei TIAN
;
Yuanhong XU
;
Jilu SHEN
;
Bin SHAN
;
Yan DU
;
Chao ZHUO
;
Danhong SU
;
Hong ZHANG
;
Jing KONG
;
Lianhua WEI
;
Ling WU
;
Yunjian HU
;
Xiaoman AI
- Publication Type:Journal Article
- From:
Chinese Journal of Infection and Chemotherapy
2014;(5):365-374
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the susceptibility and resistance of clinical isolates collected from hospitals in several regions of China . Methods Fourteen general hospitals and two children ’ s hospitals were involved in this program . Antimicrobial susceptibility testing was carried out according to a unified protocol using Kirby-Bauer method or automated Systems .Results were analyzed according to CLSI 2013 breakpoints .Results A total of 84 572 clinical isolates were collected from January to December 2013 ,of which gram negative organisms and gram positive cocci accounted for 73 .0% and 27 .0%respectively .Methicillin-resistant strains in S .aureus (MRSA) and coagulase negative Staphylococcus (MRCNS) accounted for an average of 45 .2% and 73 .5% respectively .The resistance rates of methicillin-resistant strains to β-lactams and other antimicrobial agents were much higher than those of methicillin-susceptible strains .However ,92 .2% of MRSA strains were still susceptible to trimethoprim-sulfamethoxazole while 87 .4% of MRCNS strains were susceptible to rifampin . No staphylococcal strains were found resistant to vancomycin ,teicoplanin or linezolid .In Enterococcus spp .,the resistance rates of E . f aecalis strains to most tested drugs (except chloramphenicol) were much lower than those of E . f aecium .Some strains of both species were resistant to vancomycin .Vancomycin-resistant strains of E . f aecalis and E . f aecium were mainly VanA type based on their phenotype .Regarding non-meningitis S . pneumoniae strains ,the prevalence of penicillin-susceptible S . pneumoniae and penicillin-intermediate S . pneumoniae strains isolated from both adults and children were lower than those isolated in 2012 ,but the prevalence of penicillin-resistant S .pneumoniae strains increased .The prevalence of ESBLs producing strains was 54 .0% in E .coli ,31 .8% in Klebsiella spp .(K .pneumoniae and K .oxytoca) and 16 .5% in Proteus mirabilis isolates on average . ESBLs-producing Enterobacteriaceae strains were more resistant than non-ESBLs-producing strains in terms of antibiotic resistance rates .The strains of Enterobacteriaceae were still highly susceptible to carbapenems .Overall less than 7 .0% of these strains were resistant to carbapenems .About 62 .8% and 59 .4% of Acinetobacter spp .(A .baumannii accounts for 89 .2% ) strains were resistant to imipenem and meropenem ,respectively .Compared with the data of year 2012 , extensively-drug resistant strains in K . pneumoniae and A . baumannii decreased .Conclusions The antibiotic resistance of clinical bacterial isolates is growing in 2013 .The disseminated multi-drug or pan-drug resistant strains in a special region poses a serious threat to clinical practice and implies the importance of strengthening infection control .
