Observation of heart functions in patients with cancer receiving combined chemotherapy of paclitaxel plus cisplatin using cardiac troponin level and speckle tracking echocardiography
- VernacularTitle:肌钙蛋白测定和超声2 D-STI观察紫杉醇联合顺铂方案对心脏的亚临床损害
- Author:
Jianqiong CHEN
;
Guoping SUN
;
Ling WANG
- Publication Type:Journal Article
- Keywords:
chemotherapy;
cardiotoxicity;
cardiac troponin;
speckle tracking imaging
- From:
Acta Universitatis Medicinalis Anhui
2014;(9):1314-1316
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe heart functions of the patient with cancer receiving combined chemotherapy of paclitaxel plus cisplatin through troponin test and speckle tracking echocardiography. Methods 43 patients who had been scheduled to receive combined chemotherapy of paclitaxel plus cisplatin were recruited in the study. Ser-um cTnT and cTnI levels were measured before chemotherapy,after the first cycle of chemotherapy,middle cycle of chemotherapy and after the last cycle of chemotherapy. In all patients, the lobal longitudinal systolic strain( GSL) and strain rate(GSRs)of the LV as well as peak early-diastolic strain rate (GSRe) and peak late-diastolic strain rate ( GSRa) were measured by two-dimensional speckle tracking echocardiography at every stage. Results The patients' serum cTnT and cTnI level after chemotherapy were increased gradually(P<0.01). After the last stage of chemotherapy the GSL and GSRs decreased significantly, having made significance in statistics ( P <0.01 ) . Compared with those before chemotherapy, the patients' GSRe and GSRa in the early stage of chemotherapy had no significant difference (P>0. 05), but compared to those of the middle and last stage of chemotherapy, significant difference (P<0.01) existed. Conclusion Paclitaxel plus cisplatin induce certain subclinical myocardial injury to patient's heart. Cardiac troponin level and speckle tracking echocardiography have important value in the obser-vation of heart functions of the patients with cancer receiving chemotherapy.
