CHINET surveillance of distribution and susceptibility of carbapenem-resistant Enterobacteriaceae isolates in 2012
- VernacularTitle:2012年中国CHINET碳青霉烯类耐药肠杆菌科细菌的分布特点和耐药性分析
- Author:
Fupin HU
;
Demei ZHU
;
Fu WANG
;
Yunsong YU
;
Jie LIN
;
Yunjian HU
;
Xiaoman AI
;
Zhidong HU
;
Jin LI
;
Yuanhong XU
;
Jilu SHEN
;
Hong ZHANG
;
Jing KONG
;
Zhaoxia ZHANG
;
Ping JI
;
Chuanqing WANG
;
Aimin WANG
;
Yuxing NI
;
Jingyong SUN
;
Ziyong SUN
;
Zhongju CHEN
;
Chao ZHUO
;
Danhong SU
;
Yingchun XU
;
Xiaojiang ZHANG
;
Lianhua WEI
;
Ling WU
;
Bin SHAN
;
Yan DU
;
Baiyi CHEN
;
Yunzhuo CHU
- Publication Type:Journal Article
- Keywords: bacterial resistance surveillance; antimicrobial susceptibility testing; carbapenem-resistant Enterobacteriaceae; infection control
- From: Chinese Journal of Infection and Chemotherapy 2014;(5):382-386
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the distribution and susceptibility of carbapenem-resistant Enterobacteriaceae (CRE) isolates in 2012 from CHINET surveillance .Methods Antimicrobial susceptibility testing was carried out according to a unified protocol using Kirby-Bauer method or automated Systems .Results were analyzed according to the breakpoints of CLSI 2012 M100-S22 .Results A total of 1 499 CRE isolates were collected from January to December 2012 ,of which K lebsiella spp .,Enterobacter spp .and E .coli accounted for 63 .5% ,15 .1% and 13 .7% ,respectively .Of the 1 499 isolates , 48 .2% and 29 .3% were from respiratory tract and ICU , respectively . The results of antimicrobial susceptibility testing showed that the resistance rate of CRE isolates to most antimicrobial agents was 70 .0%-100% except amikacin (46 .9% ) and trimethoprim-sulfamethoxazole (49 .8% ) .CRE isolates from adults were more resistant to ciprofloxacin ,aminoglycosides and trimethoprim-sulfamethoxazole than those from children .Conclusions The antibiotic resistance of CRE isolates is very high . The spread of CRE strains in a specific region such as ICU and neurosurgery ward poses a serious threat to clinical practice and implies the importance of strengthening infection control .