CHINET 2012 surveillance of antibiotic resistance in Acinetobacter baumannii isolates in China
- VernacularTitle:2012年中国CHINET不动杆菌属细菌耐药性监测
- Author:
Hui ZHANG
;
Xiaojiang ZHANG
;
Yingchun XU
;
Zhidong HU
;
Jin LI
;
Ziyong SUN
;
Cui JIAN
;
Fu WANG
;
Demei ZHU
;
Chao ZHUO
;
Danhong SU
;
Yunzhuo CHU
;
Yunsong YU
;
Jie LIN
;
Yuanhong XU
;
Jilu SHEN
;
Yuxing NI
;
Jingyong SUN
;
Zhaoxia ZHANG
;
Ping JI
;
Lianhua WEI
;
Ling WU
;
Chuanqing WANG
;
Jianchang XUE
;
Hong ZHANG
;
Wanhua LI
;
Yunjian HU
;
Xiaoman AI
;
Bin SHAN
;
Yan DU
- Publication Type:Journal Article
- Keywords: A cinetobacter baumannii; multidrug-resistant; antimicrobial agent
- From: Chinese Journal of Infection and Chemotherapy 2014;(5):392-397
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the antimicrobial resistance in the A cinetobacter baumannii strains in different parts of China during 2012 .Methods A total of 8 739 clinical isolates of Acinetobacter were collected from 13 general hospitals and two children’s hospitals ,of which most were A . baumannii (89 .6% , 7 827/8 739 ) . Antimicrobial susceptibility testing was carried out by means of Kirby-Bauer method according to the unified protocol . The susceptibility testing data were analyzed by WHONET 5 .6 software according to CLSI 2013 breakpoints .Results Majority (85 .4% ) of the Acinetobacter strains were isolated from inpatients .The remaining 14 .6% were from outpatients and emergency room patients .Of the 7 827 strains of A .baumannii , 10 .9% ,35 .2% ,35 .7% and 43 .4% were resistant to tigecycline ,minocycline ,cefoperazone-sulbactam and amikacin , respectively .The percentage of A .baumannii resistant to imipenem and meropenem was 63 .5% and 68 .2% ,respectively . The antimicrobial resistant pattern varied in different hospitals . The resistance of A . baumannii varied between different clinical departments .A number of pandrug resistant (PDR) (20 .0% ,1 567/7 827) and multidrug-resistant (MDR) (45 .0% , 3 521/7 827 ) A . baumannii were identified . Conclusions A . baumannii is the most popular pathogenic bacteria among Acinetobacter .The antibiotic resistance of A .baumannii is still increasing .Cefoperazone-sulbactam and minocycline has good in vitro antibacterial activity against A .baumannii .The antibiotic resistance of A .baumannii varies greatly with hospital and department .