CHINET 2012 surveillance of antibiotic resistance in Klebsiella spp .in China
- VernacularTitle:2012年中国CHINET克雷伯菌属细菌耐药性监测
- Author:
Jing GUAN
;
Chao ZHUO
;
Danhong SU
;
Yuxing NI
;
Jingyong SUN
;
Fu WANG
;
Demei ZHU
;
Fupin HU
;
Yingchun XU
;
Xiaojiang ZHANG
;
Yunsong YU
;
Qing YANG
;
Zhongju CHEN
;
Ziyong SUN
;
Zhaoxia ZHANG
;
Ping JI
;
Bin SHAN
;
Yan DU
;
Hong ZHANG
;
Jing KONG
;
Yuanhong XU
;
Jilu SHEN
;
Chuanqing WANG
;
Aimin WANG
;
Zhidong HU
;
Quan LI
;
Lianhua WEI
;
Ling WU
;
Yunjian HU
;
Xiaoman AI
- Publication Type:Journal Article
- Keywords: Klebsiella; antibiotic resistance surveillance; antimicrobial susceptibility testing
- From: Chinese Journal of Infection and Chemotherapy 2014;(5):398-404
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the antimicrobial resistance of clinical strains of K lebsiella spp .isolated from 15 hospitals in China CHINET during 2012 .Methods Kirby-Bauer method and automatic microbiology analysis system were employed to study the antimicrobial resistance . WHONET 5 .6 software was applied for data analysis according to Clinical and Laboratory Standards Institute (CLSI) 2012 breakpoints .Results A total of 9 621 clinical K lebsiella isolates were analyzed ,including 8 772 strains of K . pneumoniae and 804 strains of K . oxytoca . About 54 .9% (5 285/9 621) of the K lebsiella strains were isolated from sputum ,and 16 .3% (1 564/9 621) were isolated from pediatric patients .Antimicrobial susceptibility testing showed that about 8 .9% ,10 .8% and 12 .9% of the strains were resistant to imipenem ,meropenem and ertapenem ,respectively .About 14 .1% and 17 .0% of the strains were resistant to piperacillin-tazobactam and cefoperazone-sulbactam , respectively . Carbapenem-resistant K lebsiella strains were identified from all the 15 hospitals ,including 945 strains of K .pneumoniae and 45 strains of K .oxytoca ,which were resistant to either imipenem ,meropenem or ertapenem .Conclusions The Klebsiella isolates collected from 15 hospitals in China during 2012 are relatively sensitive to carbapenems ,cefoperazone-sulbactam and piperacillin-tazobactam .The prevalence of carbapenem-resistant strains is still increasing in China ,about 10 .3% in 2012 ,and relatively higher in Eastern China .More efforts should be made to control the superbug .