Antibiotic resistance of the Haemophilus inf luenzae strains isolated from respiratory tract in children
- VernacularTitle:儿童呼吸道流感嗜血杆菌的耐药性分析
- Author:
Xiaohua YANG
;
Nan TAN
;
Aixin LIN
;
Weishan WANG
- Publication Type:Journal Article
- Keywords:
Haemophilus influenzae;
children;
antibiotic resistance;
beta-lactamase
- From:
Chinese Journal of Infection and Chemotherapy
2014;(5):436-439
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the antibiotic resistance of Haemophilus influenzae isolates collected from the children with respiratory tract infection for rational use of antibiotics in clinical practice .Methods The H .influenzae strains were isolated from children and subjected to antimicrobial susceptibility testing by Kirby-Bauer method .Nitrocefin disc test was used to detect the production of beta-lactamases .WHONET 5 .6 software was used to analyze the susceptibility data .Results A totalof1256strainsof H.influenzaewereisolated.About37.8% ,65.5% and16.5% ofthe1256strainsof H.influenzae were resistant to ampicillin ,trimethoprim-sulfamethoxazole ,and ampicillin-sulbactam ,respectively .Less than 10 .0% of these strains were resistant to any other antibiotics tested .Beta-lactamase was produced in 33 .5% of the 1 256 strains of H . influenzae .Conclusions The H . influenzae strains in this study are mainly resistant ampicillin and trimethoprim-sulfamethoxazole .About 80 .0% of these H . influenzae strains were still susceptible to cefaclor ,ampicillin-sulbactam , cefixime ,ceftazidime ,azithromycin ,ciprofloxacin ,meropenem and rifampin .The primary mechanism of ampicillin resistance in Haemophilus is production of beta-lactamases .
