Advance in function of deubiquitination enzyme BRCC36
10.3969/j.issn.1000-4718.2014.09.030
- VernacularTitle:去泛素化酶 BRCC36功能的研究进展
- Author:
Rujun LI
;
Kaizheng GONG
;
Zhengang ZHANG
- Publication Type:Journal Article
- Keywords:
BRCC36 protein;
Ubiquitination;
DNA damage repair;
Neoplasms;
Heart diseases
- From:
Chinese Journal of Pathophysiology
2014;(9):1713-1716
- CountryChina
- Language:Chinese
-
Abstract:
The protein of BRCC36 is a kind of enzyme specifically hydrolyzing K 63-linked poly-ubiquitin chain and widely found in a variety of eukaryotic cells .BRCC36 recognizes diverse substrate proteins , and participates in various kinds of pathophysiological responses such as DNA damage repair , cell signal transduction and cell cycle control .It plays an important role in the process of cancer , angiogenesis and cardiac injury .This review discusses the progress in the inves-tigation on BRCC36 protein to provide the necessary information for searching new therapeutic targets of many diseases .
