Efficacy of Quadruple Therapy Combined with Astragalus Membranaceus for Eradication of Helicobacter pylori
10.3969/j.issn.1008-7125.2014.08.008
- VernacularTitle:四联疗法联合黄芪颗粒根除幽门螺杆菌的临床研究
- Author:
Changzhou CHEN
;
Li LI
;
Zhijian GU
;
Zhengli ZHANG
;
Jiang LIN
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Eradication Rate;
Astragalus Membranaceus;
Quadruple Therapy;
Chronic Gastritis with Dyspepsia;
Peptic Ulcer
- From:
Chinese Journal of Gastroenterology
2014;(8):482-485
- CountryChina
- Language:Chinese
-
Abstract:
Background:In the treatment of many gastric diseases,eradication of Helicobacter pylori( Hp)is important. With the increasing in antibiotic resistance of Hp,the eradication efficacy of conventional triple and quadruple therapy for Hp is decreasing in recent years. Aims:To assess the efficacy and safety of quadruple therapy combined with astragalus membranaceus for Hp eradication. Methods:A total of 395 Hp-infected patients with chronic gastritis/dyspepsia and peptic ulcer diagnosed by gastroscopy were enrolled,of them 185 patients were of chronic gastritis/dyspepsia group and 210 patients were of peptic ulcer group. Patients in the two groups were subdivided into trial group and control group. Patients in trial group were given quadruple therapy combined with astragalus membranaceus for 14 days,and patients in control group were given quadruple therapy only for 14 days. Hp eradication was assessed by 13 C-urea breath test 4 weeks after treatment. Results:A total of 358 patients(90. 6%)completed the study. In chronic gastritis/dyspepsia group,the eradication rate was significantly higher in trial group than in control group by PP analysis(P<0. 05),but no significant difference was found by ITT analysis(P>0. 05). In peptic ulcer group,the eradication rates by PP and ITT analysis showed no significant differences between trial group and control group(P>0. 05). In control group,the eradication rates by PP and ITT analysis were significantly higher in peptic ulcer group than in chronic gastritis/dyspepsia group( P <0. 01). In trial group,the eradication rates by PP and ITT analysis were not significantly different between chronic gastritis/dyspepsia group and peptic ulcer group( P >0. 05 ). The incidence of adverse effects was not significantly different between chronic gastritis/dyspepsia group and peptic ulcer group as well as trial group and control group( P>0. 05). Conclusions:Quadruple therapy combined with astragalus membranaceus could increase the eradication rate of Hp in chronic gastritis/dyspepsia group safely.
