Effect of Quetiapine on Brain-derived Neurotrophic Factors in Patients with First-episode Schizophrenia
10.3870/yydb.2014.09.018
- VernacularTitle:奎硫平对首发精神分裂症患者脑源性营养因子的影响
- Author:
Jianjun LIU
;
Jushui SUN
;
Xinhua SHEN
;
Hua ZHONG
;
Weigang GUO
;
Shengli ZHI
;
Guangming SONG
;
Qiuxia XU
- Publication Type:Journal Article
- Keywords:
Quetiapine;
Schizophrenia;
Neurotrophic factors,brain-derived;
Cognitive function
- From:
Herald of Medicine
2014;(9):1185-1187
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of quetiapine on serum levels of brain-derived neurotrophic factors ( BDNF) and the correlation between BDNF and psychiatric symptoms and cognitive function in patients with first-episode schizophrenia. Methods Eighty patients with first-episode schizophrenia ( treatment group) were treated with quetiapine orally for 4 weeks,at initial dose of 100 mg·d-1 and average dose of (580±120) mg·d-1 . The psychiatric symptoms were evaluated by using the positive and negative syndrome scale ( PANSS) . The cognitive function was assessed by using Wisconsin cards sort test ( WCST) . The serum BDNF level was detected with enzyme-linked immunosorbent assay ( ELISA) . Results The serum level of BDNF was markedly lower in schizophrenic patients before[(13. 72±8. 79) ng·mL-1,P<0. 01] and after treatment[(18. 02±9.06) ng·mL-1,P<0.05]in comparison with normal controls(23. 67±10. 13) ng·mL-1]. After treatment,the PANSS total scores and subscale scores decreased,WCST number of categories and the number of correct answers increased,and the number of wrong answers reduced. There was a positive correlation between the serum BDNF and negative symptoms ( SANS) ( r= 0. 54, P=0. 032),and the number of correct answers. Conclusion The quetiapine significantly increases serum level of BDNF in schizophrenia patients,which correlates positively with improvements in symptoms and cognitive function.
