The role of oxidative stress induced histone modification in chronic obstructive pulmonary disease
- VernacularTitle:氧化应激致组蛋白修饰在慢性阻塞性肺病发生发展中的作用
- Author:
Lingwen KONG
;
Jingcheng DONG
- Publication Type:Journal Article
- Keywords:
Histone;
Chronic obstructive pulmonary disease;
Oxidative Stress;
Histone Deacetylase;
Sirt 1
- From:
Journal of Medical Postgraduates
2014;(9):968-972
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary disease ( COPD) is a prevalent disease which is the fourth leading cause of death worldwide and will be the major economic burden of diseases according to the World Bank /World Health Organization .However , the pathogenesis of COPD is inadequately understood , oxidative stress and chronic inflammation are considered to be two independent path -ogenetic factors , but the epigenetic put them together because of changes of the environment lead to gene abnormal expression .This ar-ticle summarizes the relationship between histone modifications of genes induced by oxidative stress and the inflammation , antioxidant response, apoptosis, autophagy and the differentiation of T cell subsets in the pathogenesis of COPD .The work will provide more choices for clinical treatment of COPD .
