Advance research on protein tyrosine phosphatase SHP-2 and the regulating role of it in osteoclastogenesis
- VernacularTitle:SH P-2及其调节破骨细胞形成作用的研究进展
- Author:
Peng LIN
;
Huan JIANG
;
Min HU
- Publication Type:Journal Article
- Keywords:
Protein tyrosine phosphatases;
SHP-2;
Osteoclasts;
Bone metabolism
- From:
Journal of Medical Postgraduates
2014;(9):990-993
- CountryChina
- Language:Chinese
-
Abstract:
SHP-2 is one of the protein tyrosine phosphatases which plays a role in the progress of dephosphorylation in organ -isms, participating in many kinds of signal transduction pathways .The mutation of SHP-2 is associated with many kinds of malignant diseases .In recent years , scholars have found that SHP-2 is the key factor in osteoclastogenesis , playing a positive role in the progress of reversible phosphorylation of osteoclasts .The objective of this article is to review the molecular biological characteristics of SHP-2, th diseases associated with the mutation of SHP-2 and the effects of SHP-2 in regulation of osteoclastogenesis .
