The progress on the association of tissue and cell damage with free fatty acids
- VernacularTitle:游离脂肪酸与组织细胞损伤相关性的研究进展
- Author:
Tao YUAN
;
Jianning ZHAO
;
Nirong BAO
- Publication Type:Journal Article
- Keywords:
Free fatty acids;
Erythrocytes injury;
Reactive oxygen species;
Oxidative stress
- From:
Journal of Medical Postgraduates
2014;(9):994-997
- CountryChina
- Language:Chinese
-
Abstract:
Free fatty acids generated from the metabolites of fat have been demonstrated to stimulate the neutrophils to produce reactive oxygen species ( ROS) such as hydrogen peroxide and chlorous peroxide .It has shown that free fatty acid is closely related with myocardial, vascular endothelium, liver, lung and other tissue damage.The mechanism of erythrocyte injury is oxidation of mem-brane polyunsaturated fatty acids and cytosolic hemoglobin by ROS .High levels of free fatty acids can increase the formation of active reaction molecular ROS , thus initiating the oxidative stress reaction .Active molecules can oxalate and damage the DNA , protein, lipid and other molecules of RBC .It has revealed the relationship between free fatty acids and erythrocytes injury , which provided a new di-rection in the research of oxidative anemia .This article reviews the advances in the research of this subject in recent years .
