Protective Effects of Acanthoic Acid on Acute Liver Injury in Mice
10.3870/yydb.2014.09.002
- VernacularTitle:刺五加酸对急性肝损伤小鼠的保护作用
- Author:
Chengyi HAO
;
Yanling WU
;
Lihua LIAN
;
Jixing NAN
- Publication Type:Journal Article
- Keywords:
Acanthoic acid;
Tacrine;
Liver diseases
- From:
Herald of Medicine
2014;(9):1126-1128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study protective effects of acanthoic acid ( AA) against acute liver injury. Methods Sixty mice were randomly divided into six groups (n=10 each),including normal control group,model control group,positive control group (N-acetyl -L- cysteine,NAC,300 mg·kg-1),and AA at small (50 mg·kg-1),middle (100 mg·kg-1),and high (200 mg·kg-1 ) dose groups. Each group received respective treatment for 3 days and fasted for 16 h before the last dose. All animals except of the normal control group were treated with tacrine (35 mg·kg-1 ) 1 h after the treatments. Hepatic pathological and serum biochemical changes were observed. Results The high-dose of AA significantly reduced the levels of AST (143±46) U·L-1 ,ALT (32±9) U·L-1 ,LDH (1 218±312) U·L-1 ,MDA (3. 24±0. 48) μmol·g-1 ,and GSH (417±15) mg·g-1 compared with the model control group (P<0. 05 or P<0. 01). Liver injury was also ameliorated in AA high dose group.Conclusion AA has a protective effect on acute liver injury in mice.
