ExPression of PeriPheral blood heat shock Protein-90 in Patients with hyPertensive disorders comPlicating Pregnancy
l0.3760/cma.j.issn.l008-63l5.20l4.l3.037
- VernacularTitle:热休克蛋白90在妊娠期高血压疾病患者血清中的表达及临床意义
- Author:
Mei YU
;
Xueqin LIU
;
Zhifen YANG
;
Xueling ZHANG
;
Xia LI
- Publication Type:Journal Article
- Keywords:
HSP90;
Hypertensive disorders complicatinG preGnancy;
Preeclampsia
- From:
Clinical Medicine of China
2014;(z1):85-87
- CountryChina
- Language:Chinese
-
Abstract:
Objective ThrouGh the detection of heat shock protein 90(HSP90)Gene expression in the peripheral blood in in patients with hypertensive disorders complicatinG preGnancy( HDCP ),to understand its role in the pathophysioloGy of HDCP. Methods The expression of HSP90 was observed in Groups of normal preGnant women,Gestational hypertension patients,mild preeclampsia patients,severe preeclampsia patients by ELISA. Results The expression of HSP90 in peripheral blood of Gestational hypertension Group,mild preeclampsia Group,severe preeclampsia Group were siGnificantly hiGher than normal preGnant Group( P<0. 0l ) . Conclusion HSP90 may have close relationship with the onset and development of HDCP. It can predict HDCP by detectinG the level of HSP90 in peripheral blood.
