Diagnosis and treatment of primary melanocytoma in central nervous system
- VernacularTitle:中枢神经系统原发性黑色素细胞瘤的治疗体会
- Author:
Yuan ZHOU
;
Handong WANG
;
Chiyuan MA
;
Huilin CHENG
;
Youwu FAN
;
Kaidong LIU
;
Ning LI
;
Jin HE
- Publication Type:Journal Article
- Keywords:
Central nervous system;
Melanocytoma;
Diagnosis and treatment
- From:
Journal of Medical Postgraduates
2014;(9):952-954
- CountryChina
- Language:Chinese
-
Abstract:
Objective There are differences in the diagnosis and treatment of primary melanocytoma in central nervous sys -tem.The article was to investigate the experience of its diagnosis and treatment . Methods Retrospective analysis were made on the clinical data of 14 cases with primary melanocytoma in central nervous system ( CNS) from January 1999 to December 2012, among which were 5 males and 9 females.The incidence ages were 14-52, average 32.7.The course of disease ranged from half a month to 19 years, geometric average 7.9 months.5 cases recurred and 9 cases occurred first.10 cases were intracranial and 4 were intraspinal. Results 14 patients underwent surgery and had pathologic diagnosis of melanocytoma .Total resection was performed in 7 patients, subtotal resection in 3, and partial resection in 1.Immunohistochemical study showed , in all cases, S-100 and HMB-45 were positive, GFAP and EMA were negative .Vimentin was positive in 8 cases and MelanA positive in 5 cases.12 cases recovered well and dis-charged except for paraplegia and facial paralysis in 1 case each. Conclusion Primary melanocytoma in CNS is very rare .Diagnosis is based on intraoperative findings , surgical pathology and immunohistochemistry results .Surgery is the primary therapy and early total resection is advocated .Adjuvant radiotherapy can reduce the recurrence rate .
