Cellular signal transduction of the hypoxia response
- VernacularTitle:细胞的缺氧信号转导通路
- Author:
Feifei HAN
;
Guoqian CHEN
- Publication Type:Journal Article
- Keywords:
Hypoxia;
Hypoxia-inducible factor-1;
Signal transduction
- From:
Journal of Medical Postgraduates
2014;(9):982-985
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia is a common physiological and pathological stimulus in many human diseases .The cellular oxygen sensors and the following activation of multiple cellular signal transduction pathways involved in hypoxia responses can regulate cell survival as well as respiration , blood circulation , metabolism and so forth .The cell response to hypoxia has a complex diversity .Hypoxia-induc-ible factor ( HIF) pathway in an oxygen dependent manner plays a central role during the hypoxia response .The HIF-independent path-ways are equally important under hypoxic conditions which can maintain the oxygen balance and metabolism balance .
