Tumor Inhibition of Acid-Responsive Polymer-Cisplatin Conjugate Nanoparticles Drug Delivery System

VernacularTitle:酸响应聚合物-铂共轭纳米颗粒给药载体的抑癌作用
Author: Tao LIANG
Publication Type:Journal Article
Keywords: Cisplatin; Nanoparticles,polymer; Acid-responsive; Drug delivery; Drug release; Cytotoxicity
From: Herald of Medicine 2014;(9):1132-1136
CountryChina
Language:Chinese
Abstract: Objective To synthesize polymer-cisplatin conjugate nanoparticles for acid-responsive drug delivery, and verify the inhibitory effect of the nano-system on cancer cells. Methods Acid-responsive polymer-cisplatin conjugate nano-drug carrier was synthesized to simulate the drug release under an acidic environment. Cell viability was examined by MTT assay. Results The polymer-cisplatin nanoparticles exhibited well-controlled cisplatin loading rate, and excellent acid-responsive drug release kinetics. At pH 7. 4, little drug was released. At pH 5. 0 or 6. 0,the drug release was significant. Compared with free cisplatin,cisplatin in the conjugate nanoparticles showed higher cytotoxicity against ovarian cancer cells in vitro. An equivalent dose of 7 μmol·L-1 cisplatin loaded in the conjugate nanoparticles exhibited same cytotoxicity as 50μmol·L-1 free cisplatin.Conclusion Polymer-cisplatin conjugate is an acid-responsive drug delivery system that greatly improves the bioavailability of cisplatin to tumor cells. It is expected to play a better tumor inhibition effect by quickly releasing a high dose of chemotherapy drug inside tumor cells.