Protective Effects of Schisandra Lignans Against Doxorubicin-Induced Liver Injury in Rats
10.3870/yydb.2014.09.005
- VernacularTitle:五味子木脂素对多柔比星诱导肝损伤大鼠的保护作用
- Author:
Ying AN
;
Yanchun WANG
;
Lu XU
;
Hongyan FAN
;
Nan SHEN
;
Lijing ZHAO
;
Xue CHEN
;
Bo XU
- Publication Type:Journal Article
- Keywords:
Schisandra lignans;
Doxorubicin;
Liver diseases
- From:
Herald of Medicine
2014;(9):1136-1139
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate protective effects of schisandra lignans on doxorubicin-induced liver injury in rats. Methods SD rats were randomly divided into six groups: normal control, model control, vitamin C and schisandra lignans at small, middle, and high doses. The liver injury model was established by intraperitoneal injection of doxorubicin. Normal controls were intragastrically administrated with 0. 9%sodium chloride solution,while other groups were administrated with different medications,respectively. Interleukin-10 (IL-10) in serum,nitric oxide (NO) and aspartate aminotransferase (AST) in liver tissue homogenate were measured. Histopathological changes in hepatic tissues were also observed. Results Serum IL-10 and tissue NO were obviously lower in the model control group than those in other groups,while those in all schisandra lignans treated groups were significantly improved (P<0. 05, P<0. 01). The AST level in schisandra lignans middle- and high dose groups was (372. 58±105. 80) and (327. 92±42. 80) U·g-1 ,respectively,significantly lower than (565. 07±22. 13) U·g-1 in the model control group (P<0. 05,P<0. 01). Histopathological analysis showed that degeneration and necrosis of hepatocytes were remarkably alleviated in all schisandra lignans treated groups. Conclusion Schisandra lignans protect rats against doxorubicin-induced liver injury.
