Expression of SNCG and CXCR4 mRNAs in gastric adenocarcinoma and its clinical significance
10.3969/j.issn.1000-8179.20140242
- VernacularTitle:胃癌组织中SNCG和CXCR4 mRNA的表达及临床意义
- Author:
Shufang ZHENG
;
Lifang SHI
;
Jian YU
- Publication Type:Journal Article
- Keywords:
SNCG;
CXCR4;
gastric cancer;
infiltration;
metastasis
- From:
Chinese Journal of Clinical Oncology
2014;(17):1094-1097
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect expression of SNCG and CXCR4 mRNA in gastric adenocarcinoma and evaluate its function in carcinogenesis, progression, infiltration, and metastasis, as well as the correlation of these proteins. Methods:The expression of SNCG and CXCR4 mRNAs was detected using reverse transcription-polymerase chain reaction in gastric adenocarcinoma and normal gastric mucosa. Results:The expression of SNCG and CXCR4 mRNAs was obviously higher in gastric adenocarcinoma than in normal gastric mucosa (P<0.01). The expression of SNCG mRNA was closely correlated with tumor infiltration depth (P<0.05) and lymph node metas-tasis (P<0.01). The expression of CXCR4 mRNA closely correlated with lymph node metastasis (P<0.01). The expression of SNCG and CXCR4 mRNAs positively correlated in 29 cases of gastric adenocarcinoma (r=0.346, P<0.05). Conclusion:SNCG and CXCR4 may be overexpressed in tumor tissue and may have important functions in tumorigenesis, progression, infiltration, and metastasis of gastric adenocarcinoma.
