Methodology and clinical significance of detecting EGFR-T790M mutation in advanced non-small cell lung cancer
10.3969/j.issn.1000-8179.20141068
- VernacularTitle:晚期非小细胞肺癌T790M突变的检测方法及临床意义
- Author:
Qiuyi ZHANG
;
Yilong WU
;
Qing ZHOU
- Publication Type:Journal Article
- Keywords:
non-small cell lung cancer;
epidermal growth factor receptor;
T790M mutation;
quantitative detection
- From:
Chinese Journal of Clinical Oncology
2014;(17):1125-1127
- CountryChina
- Language:Chinese
-
Abstract:
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) comprise an effective therapy for advanced non-small cell lung cancer patients with EGFR-activating mutations. Unfortunately, most patients eventually develop resistance to EG-FR-TKIs, probably due to a secondary point mutation of EGFR T790M. Thus, a sensitive method for accurate detection of T790M mu-tation is essential. Peripheral blood detection has gained our attention because it is convenient, making dynamic noninvasive quantita-tive detection of T790M mutation an optimal means of monitoring the efficacy of EGFR-TKIs. To date, the clinical significance of T790M mutation and EGFR-TKI resistance remains controversial. Several EGFR-TKIs targeting EGFR mutation, which have been in-troduced in recent years, showed better response in patients with T790M mutation, indicating that T790M may be a biomarker for con-quering resistance. This review introduces the methodology of T790M detection and its role in clinical practice.
