Progress on GSK-3βparticipating in neuropsychiatric disorders
10.3969/j.issn.1001-1978.2014.09.003
- VernacularTitle:GSK-3β参与神经精神疾病的研究进展
- Author:
Qianqian TANG
;
Xiaoyun GUO
;
Di LIU
;
Junli CAO
- Publication Type:Journal Article
- Keywords:
GSK-3β;
PI3K;
Wnt signaling pathway;
bipolar dis-order;
schizophrenia;
Alzheimer's disease;
pain
- From:
Chinese Pharmacological Bulletin
2014;(9):1193-1196
- CountryChina
- Language:Chinese
-
Abstract:
Glycogen synthase kinase-3β( GSK-3β) is a serine-threonine kinase,which was originally identified as a key regula-tor of glycogen metabolism. In nervous system, GSK-3β partici-pates in many central and peripheral nervous system physiological processes through transcription,cell proliferation and differentia-tion. The abnormal activity of GSK-3βinduces downstream signa-ling molecules and gene expression abnormalities,which are in-volved in some neuropsychiatric disorders such as schizophrenia, bipolar disorder,Alzheimer's disease,and pain. In recent years, lots of basic and clinic researches focus on GSK-3β,which might gradually become critical theraptic target of many diseases. The article mainly reviews the mechanisms involved in abnormal acti-vation of GSK-3β related neuropsychiatric disorders.
